The dynamic epigenetic landscape directs gene expression patterns that dictate cellular
form and function, and drive the assembly of cells into tissues. The high degree of plasticity …

Change of biophysical factors in tissue microenvironment is an important step in a chronic
disease development process. A mechanical and biochemical factor from cell living …

Stem cells secrete trophic factors that induce angiogenesis. These soluble factors are
promising candidates for stem cell–based therapies, especially for cardiovascular diseases …

Mesenchymal stem cell therapy has suffered from wide variability in clinical efficacy, largely
due to heterogeneous starting cell populations and large‐scale cell death during and after …

Introduction The propagation of mechanochemical signals from the extracellular matrix to
the cell nucleus has emerged as a central feature in regulating cellular differentiation and de …

Increasing evidence from cancer cell fusion with different cell types in the tumor
microenvironment has suggested a probable mechanism for how metastasis-initiating cells …

Fine tuning of the substrate properties to modulate the function of mesenchymal stem cells
(MSCs) has emerged as an attractive strategy to optimize their therapeutic potential. In the …

Mesenchymal stem cell‐derived secretome represents an emerging acellular therapeutic
which possess significant opportunity for clinical applications due to its anti‐inflammatory …

There is an increasing need for novel biomaterials compatible with advanced biofabrication
technologies, which also permit cells to remodel their microenvironment. This remodelling is …

Exosomes have come a long way since they were first described in 1981 by Trams et al. as
small lipid bilayer-enclosed vesicles of endocytic origin. Their ability to alter cell bioactivity …