The targeted nuclease revolution (TALENs, CRISPR/Cas9) now allows Xenopus
researchers to rapidly generate custom on‐demand genetic knockout models. These novel …

Metastases are a major cause of cancer-related death and despite the fact that they have
been focus of intense research over the last two decades, effective therapies for patients …

Simple Summary A large number of estrogen receptor-positive breast cancer patients show
relapses at the metastatic site up to 20 years after the removal of the primary tumor. This …

Heart disease is the leading cause of death in the western world. Attaining a mechanistic
understanding of human heart development and homeostasis and the molecular basis of …

Simple Summary One of the worst aspects of tumors is the relapse of metastatic lesions
several years after the removal of the primary tumor and after the patient has been …

Human cytomegalovirus (HCMV) genome replication is a complex and still not completely
understood process mediated by the highly coordinated interaction of host and viral …

Bufo bufo is a living example of evolutionary processes due to its numerous physiological
and ecological adaptations. This is the first study to genetically characterize the TGF-β gene …

Ketamine is a potent dissociative anesthetic and the most commonly used illicit drug. Many
addicts are women at childbearing age. Although ketamine has been extensively studied as …

Cooperative actions of extrinsic signals and cell-intrinsic transcription factors alter gene
regulatory networks enabling cells to respond appropriately to environmental cues …

Autocrine and paracrine signalling are traditionally difficult to study due to the sub-
micromolar concentrations involved. This has proven to be especially limiting in the study of …