Mitochondria perform diverse yet interconnected functions, producing ATP and many
biosynthetic intermediates while also contributing to cellular stress responses such as …

The development of multidrug resistance to cancer chemotherapy is a major obstacle to the
effective treatment of human malignancies. It has been established that membrane proteins …

Areas and layers of the cerebral cortex are specified by genetic programs that are initiated in
progenitor cells and then, implemented in postmitotic neurons. Here, we report that Tbr1, a …

Somatic stem cell (SSC) dysfunction is typical for different progeroid phenotypes in mice with
genomic DNA repair defects. MtDNA mutagenesis in mice with defective Polg exonuclease …

DNA damage and mutations induced by oxidative stress are associated with various
different human pathologies including cancer. The facts that most human tumors are …

The mitochondrial protein apoptosis‐inducing factor (AIF) translocates to the nucleus and
induces apoptosis. Recent studies, however, have indicated the importance of AIF for …

Reactive oxygen species (ROS) are induced by a variety of endogenous and exogenous
sources. At pathologically high levels, ROS cause damage to biological molecules …

Bioremediation is one of the commonly applied remediation strategies at sites contaminated
with polycyclic aromatic hydrocarbons (PAHs). However, remediation goals are typically …

Cerebral cortical neuron degeneration occurs in brain disorders manifesting throughout life,
but the mechanisms are understood poorly. We used cultured embryonic mouse cortical …

N-terminal methylation is an important posttranslational modification that regulates
protein/DNA interactions and plays a role in many cellular processes, including DNA …