Recent studies of molecular guidance cues including the Slit family of secreted proteins
have provided new insights into the mechanisms of cell migration. Initially discovered in the …

Roundabout receptors are molecular guidance molecules that function by interaction with
Slit proteins to regulate axon guidance, neuronal migration, and leukocyte chemotaxis. We …

Direct reprogramming involves the enforced re-expression of key transcription factors to
redefine a cellular state. The nephron progenitor population of the embryonic kidney gives …

Numerous proteins targeted for the secretory pathway are increasingly implicated in
functional or pathological roles at alternative cellular destinations. The parameters that allow …

Congenital diaphragmatic hernia (CDH) is a significant cause of pediatric mortality in
humans with a heterogeneous and poorly understood etiology. Here we show that mice …

Background The interaction of nuclear and mitochondrial genes is an essential feature in
maintenance of normal cellular function. Of 82 structural subunits that make up the oxidative …

The Crim1 gene is predicted to encode a transmembrane protein containing six von
Willebrand-like cysteine-rich repeats (CRRs) similar to those in the BMP-binding antagonist …

Toxoplasma gondii is an aerobic protozoan parasite that possesses mitochondrial
antioxidant enzymes to safely dispose of oxygen radicals generated by cellular respiration …

The ability of Plasmodium falciparum–infected red blood cells (IRBCs) to bind to vascular
endothelium, thus enabling sequestration in vital host organs, is an important pathogenic …

There is an increasing number of reports that some single gene products function in more
than one cellular compartment. This review lists and categorizes the targeting mechanisms …