Carbon-oxygen (CH··· O) hydrogen bonding represents an unusual category of molecular
interactions first documented in biological structures over 4 decades ago. Although CH··· O …

Hydrogen bonds constitute a unique type of non-covalent interaction, with a critical role in
biology. Until fairly recently, the canonical view held that these bonds occur between …

Ab initio calculations are used to analyze the CH⊙⊙⊙ O interaction between F n H3-n CH
as proton donor and H2O, CH3OH, and H2CO as acceptor. The interaction is quite weak …

The OH covalent bond of conventional hydrogen bonds of the OH⊙⊙⊙ O type undergoes a
lengthening as a result of the complex formation, and the OH stretching frequency shifts to …

Although the peptide C α H group has historically not been thought to form hydrogen bonds
within proteins, ab initio quantum calculations show it to be a potent proton donor. Its binding …

Ab initio calculations are used to compare the hydrogen bonding ability of acetylene and
ethylene, and various derivatives, with the analogous properties of alkanes. Water is used …

At the heart of drug design is the discovery of molecules that bind with high affinity to their
drug targets. Biotin forms the strongest known noncovalent ligand–protein interactions with …

This study aims to cast light on the physico-chemical nature and energetic of the non-
conventional CH··· O/N H-bonds in the biologically important natural nucleobase pairs using …

Forty-five crystals of complexes between proteins and RNA molecules from the Protein Data
Bank have been statistically surveyed for the number of contacts between RNA components …

Recent studies confirm that CH... O hydrogen bonds have many, if not all, of the
spectroscopic and physical earmarks of “traditional” H-bonds. Only more recently have we …