Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating
the RB pathway have been identified in almost every human malignancy. The E2F …

Wound healing is essential to repair the skin after injury. In the epidermis, distinct stem cells
(SCs) populations contribute to wound healing. However, how SCs balance proliferation …

Background E2F transcription factors are considered to be important drivers of tumour
growth. E2F7 is an atypical E2F factor, and its role in glioblastoma remains undefined …

Abstract The Cancer Genome Atlas (TCGA) has accrued RNA-Seq-based transcriptome
data for more than 4000 cancer tissue samples across 12 cancer types, translating these …

The p53 tumor suppressor protein is a transcription factor that exerts its effects on the cell
cycle via regulation of gene expression. Although the mechanism of p53-dependent …

MicroRNA (miRNA)-based gene therapy is a robust approach to treating human cancers.
However, the low target specificity and safety issues associated with viral vectors have …

Gallbladder carcinoma (GBC), the most common malignant tumour of the bile duct, is highly
aggressive and has a poor prognosis. MicroRNA-30a-5p (miR-30a-5p) is an important …

Abstract Background: The E2F members have been divided into transcription activators
(E2F1-E2F3) and repressors (E2F4-E2F8). E2F8 with E2F7 has been known to play an …

Abstract About 50–70% of breast cancers are estrogen receptor α (ERα) positive and most of
them are sensitive to endocrine therapy including tamoxifen. However, one third of these …

Royal jelly, also called bee milk, is a source of high-quality proteins. Royal jelly proteins
serve as not only a rich source of essential amino acids and functional donors but also an …