Background Polyphenols are a class of naturally sourced compounds with widespread
distribution and an extensive array of bioactivities. However, due to their complex …

Abstract Cushing's disease (CD), or pituitary-dependent Cushing's syndrome, is a severe
endocrine disease caused by a corticotroph pituitary tumor and associated with increased …

Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an
invaluable drug target for the pharmacological management of pituitary adenomas and …

Cushing's syndrome results from lengthy and inappropriate exposure to excessive
glucocorticoids. Untreated, it has significant morbidity and mortality. The syndrome remains …

Objective: Our objective was to evaluate the published literature and reach a consensus on
the treatment of patients with ACTH-dependent Cushing's syndrome, because there is no …

Objective Cushing's disease (CD) is a rare endocrine disorder characterized by excess
secretion of ACTH due to a pituitary adenoma. Current treatment options are limited and …

Cushing's syndrome is associated with multisystem morbidity and, when suboptimally
treated, increased mortality. Medical therapy is an option for patients if surgery is not …

Background: The role of dopamine agonists in the treatment of Cushing's disease (CD) has
been previously debated. Aim: The aim of this study was to evaluate the effectiveness of …

Context: There is currently no medical therapy for Cushing's disease that targets the pituitary
adenoma. Availability of such a medical therapy would be a valuable therapeutic option for …

An impaired glucose metabolism, which often leads to the onset of diabetes mellitus (DM), is
a common complication of chronic exposure to exogenous and endogenous glucocorticoid …