Central regulation of stress-evoked peripheral immune responses

KL Chan, WC Poller, FK Swirski… - Nature Reviews …, 2023 - nature.com
Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are
associated with systemic inflammation. Recent studies have reported stress-induced …

Clinical efficacy, pharmacodynamic components, and molecular mechanisms of antiviral granules in the treatment of influenza: A systematic review

J Su, X Chen, Y Xie, M Li, Q Shang, D Zhang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance The Antiviral Granules (AG) are derived from the
classical famous prescription, which is composed of 9 traditional Chinese medicines …

E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis

Y Shi, Y Yang, W Xu, D Shi, W Xu, X Fu, Q Lv… - Cell death & …, 2022 - nature.com
Gasdermin D (GSDMD) participates in the activation of inflammasomes and pyroptosis.
Meanwhile, ubiquitination strictly regulates inflammatory responses. However, how …

Virus-host interaction networks as new antiviral drug targets for IAV and SARS-CoV-2

N Chen, B Zhang, L Deng, B Liang… - Emerging microbes & …, 2022 - Taylor & Francis
ABSTRACT Currently, SARS-CoV-2, especially the Omicron strain, is ravaging the world
and even co-infecting human beings with IAV, which is a serious threat to human public …

MAVS antagonizes human stem cell senescence as a mitochondrial stabilizer

C Wang, K Yang, X Liu, S Wang, M Song, JCI Belmonte… - Research, 2023 - spj.science.org
Mitochondrial dysfunction is a hallmark feature of cellular senescence and organ aging.
Here, we asked whether the mitochondrial antiviral signaling protein (MAVS), which is …

[HTML][HTML] Stressed snails release Angiostrongylus cantonensis (rat lungworm) larvae in their slime

RL Rollins, MCI Medeiros, RH Cowie - One Health, 2023 - Elsevier
This study investigated the influence of stress on release of Angiostrongylus cantonensis
larvae from a snail host, Parmarion martensi. We subjected 140 infected, wild-caught P …

Dissection of scientific compatibility of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia from the perspective of …

Z Jiang, Y Sun, Z Wu, M Tang, A Ye, B Tu, J Yi… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Realgar-Indigo naturalis formula (RIF), a first-line
drug for the treatment of acute promyelocytic leukemia (APL), is also a TCM formula entirely …

Synoviolin inhibits the inflammatory cytokine secretion of Müller cells by reducing NLRP3

J Zhang, C Chen, L Wu, Q Wang… - Journal of …, 2022 - jme.bioscientifica.com
The pro-inflammatory cytokines secreted by Müller cells aggregate retinal cell loss and
vascularization in diabetic retinopathy (DR). The deubiquitinase BRCA1-BRCA2-containing …

Multi-omics strategy reveals that Cordyceps sinensis ameliorates sepsis-associated acute kidney injury via reprogramming of mitochondrial energy metabolism and …

L Chen, T Yang, J Wu, G Cheng, M Zhao… - Acta Materia …, 2024 - scienceopen.com
Cordyceps sinensis (CS) has been widely used as a dietary supplement or traditional
medicine for the prevention, treatment, and prognostication of various diseases, because of …

Mfn2 is responsible for inhibition of the RIG-I/IRF7 pathway and activation of NLRP3 inflammasome in Seneca Valley virus-infected PK-15 cells to promote viral …

HD Deng, S Zhu, L Zhu, J Sun, YC Ding, FQ Li… - Frontiers in …, 2022 - frontiersin.org
Seneca Valley virus (SVV), a non-enveloped positive single-stranded virus can cause
vesicular disease in swine. However, the mechanisms by which SVV activates an innate …