Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies

H Jiang, X Zhang, X Chen, P Aramsangtienchai… - Chemical …, 2018 - ACS Publications
Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Innate lymphoid cells: major players in inflammatory diseases

M Ebbo, A Crinier, F Vély, E Vivier - Nature Reviews Immunology, 2017 - nature.com
Recent years have seen a marked increase in our understanding of innate lymphoid cells
(ILCs). ILCs can be classified into different groups based on their similarity to T cell subsets …

Dynamic protein acylation: new substrates, mechanisms, and drug targets

T Lanyon-Hogg, M Faronato, RA Serwa… - Trends in biochemical …, 2017 - cell.com
Post-translational attachment of lipids to proteins is found in all organisms, and is important
for many biological processes. Acylation with myristic and palmitic acids are among the most …

Emerging roles of DHHC-mediated protein S-palmitoylation in physiological and pathophysiological context

I De, S Sadhukhan - European journal of cell biology, 2018 - Elsevier
Protein S-palmitoylation refers to a post-translational modification (PTM) wherein palmitic
acid, a 16-carbon long saturated fatty acid gets covalently attached to Cys sidechain of a …

Protein cysteine palmitoylation in immunity and inflammation

H Lin - The FEBS journal, 2021 - Wiley Online Library
Protein cysteine palmitoylation, or S‐palmitoylation, has been known for about 40 years, and
thousands of proteins in humans are known to be modified. Because of the large number of …

The pathogenic role of innate lymphoid cells in autoimmune-related and inflammatory skin diseases

S Zhou, Q Li, H Wu, Q Lu - Cellular & Molecular Immunology, 2020 - nature.com
Innate lymphoid cells (ILCs), as an important component of the innate immune system, arise
from a common lymphoid progenitor and are located in mucosal barriers and various …

The roles of innate immune cells in atopic dermatitis

Y Pan, Y Wang, M Xu, M Zhong, X Peng… - Journal of Innate …, 2024 - karger.com
Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by
recurrent eczematous lesions and severe pruritus. The economic burden and time penalty …

BLSNet: Skin lesion detection and classification using broad learning system with incremental learning algorithm

VR Gottumukkala, N Kumaran, VC Sekhar - Expert Systems, 2022 - Wiley Online Library
Background Skin lesion detection and classification (SLDC) is extremely important in the
diagnosis of skin cancer and detection of melanoma cancer. As a result, the use of image …

[HTML][HTML] The ZDHHC13/ZDHHC17 subfamily: from biological functions to therapeutic targets of diseases

Y Zhang, S Fan, L He, L Li - Pharmacological Research, 2024 - Elsevier
The ZDHHC13/ZDHHC17 subfamily belongs to the zinc finger DHHC-domain containing
(ZDHHC) family, including ZDHHC13 and ZDHHC17. Recent studies have shown that the …

[HTML][HTML] Palmitoyl acyltransferase activity of ZDHHC13 regulates skin barrier development partly by controlling PADi3 and TGM1 protein stability

LY Chen, KR Lin, YJ Chen, YJ Chiang, KC Ho… - Journal of Investigative …, 2020 - Elsevier
Deficiency of the palmitoyl-acyl transferase ZDHHC13 compromises skin barrier
permeability and renders mice susceptible to environmental bacterial infection and …