Histamine is a transmitter in the nervous system and a signaling molecule in the gut, the
skin, and the immune system. Histaminergic neurons in mammalian brain are located …

Antihistamines targeting the histamine H1 receptor play an important role in improving and
maintaining the quality of life of patients with allergic rhinitis. For more effective and safer …

H 1-antihistamines, the mainstay of treatment for urticaria, were developed from
anticholinergic drugs more than 70 years ago. They act as inverse agonists rather than …

In this review, we compare and contrast the clinical pharmacology, efficacy, and safety of first-
generation H 1 antihistamines and second-generation H 1 antihistamines. First-generation …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

Allergic rhinitis (AR) is an inflammation of nasal mucosa mediated by IgE-associated
processes occurring independently, or concurrently with asthma. AR is characterized by …

Histamine neurons are exclusively located in the posterior hypothalamus, and project their
fibers to almost all regions of the human brain. Although a significant amount of research …

In this article, aspects of absorption, distribution, metabolism, and excretion have been
described bearing in mind the pathogenesis of allergic diseases and their possible …

This article reviews the molecular biology of the interaction of histamine with its H 1-receptor
and describes the concept that H 1-antihistamines are not receptor antagonists but are …

Antihistamines are useful medications for the treatment of a variety of allergic disorders.
Second-generation antihistamines avidly and selectively bind to peripheral histamine H 1 …