Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint damage and
even disability. Although there are various clinical therapies for RA, some patients still have …

Adenosine is an endogenous nucleoside that regulates many physiological and
pathological processes. It is derived from either the intracellular or extracellular …

The pathological condition of neuroinflammation is caused by the activation of the
neuroimmune cells astrocytes and microglia. The autacoid adenosine seems to be an …

Psoriasis is a chronic inflammatory disease of the skin associated with systemic and joint
manifestations and accompanied by comorbidities, such as metabolic syndrome and …

Pain represents an international burden and a major socio-economic public health problem.
New findings, detailed in this review, suggest that adenosine plays a significant role in …

Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and
secrete sufficient IL-1β. However, MSU alone is not sufficient to cause a flare. This is …

The molecular components of the purinergic system (ie, receptors, metabolizing enzymes
and membrane transporters) are widely expressed in the cells of the immune system …

To date, there is insufficient evidence to explain the role of adenosinergic receptors in the
reconsolidation of long-term spatial memory. In this work, the role of the adenosinergic …

Rheumatoid arthritis (RA) is a complex autoimmune inflammatory rheumatic disease
characterized by an imbalance between immunological reactivity and immune tolerance …

Alzheimer's, Parkinson's, and multiple sclerosis are neurodegenerative diseases related by
neuronal degeneration and death in specific areas of the central nervous system. These …