Hepatitis B virus (HBV) infection is one the leading risk factors for chronic hepatitis, liver
fibrosis, cirrhosis and hepatocellular cancer (HCC), which are a major global health …

Hepatitis B virus (HBV) and hepatitis C virus (HCV) cause a large proportion of acute and
chronic liver disease worldwide. Over the past decades many immunological studies …

We have previously shown that Toll‐like receptor (TLR)‐activated murine nonparenchymal
liver cells [(NPC); Kupffer cells (KC), liver sinusoidal endothelial cells (LSEC)] can suppress …

Chronic hepatitis B virus (HBV) infection is the result of an inadequate immune response
towards the virus. Myeloid dendritic cells (mDC) of patients with chronic HBV are impaired in …

Plasmacytoid dendritic cells (pDCs) play a key role in detecting pathogens by producing
large amounts of type I interferon (IFN) by sensing the presence of viral infections through …

Hepatitis viruses are chief pathogens of hepatitis and end-stage liver diseases. Their
replication and related pathogenic process highly rely on the host micro-environment and …

The concept of immune evasion is a longstanding topic of debate during chronic Hepatitis B
Virus infection. The 292 million individuals chronically infected by HBV are clear evidence …

Chronic hepatitis B (CHB) is a widespread infectious disease with unfavorable outcomes
and life-threatening consequences for patients, in spite of modern vaccination and antiviral …

BACKGROUND/AIMS: Functionally impaired dendritic cells (DCs) play important roles in
suppressing host immune responses and facilitating viral persistence in chronic hepatitis B …

Chronic hepatitis B virus (HBV) infection is caused by inadequate anti-viral immunity.
Activation of plasmacytoid dendritic cells (pDC) leading to IFNα production is important for …