Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease that usually
results in respiratory paralysis in an interval of 2 to 4 years. ALS shows a multifactorial …

Amyotrophic lateral sclerosis is a relentlessly progressive multi-system condition. The
clinical picture is dominated by upper and lower motor neuron degeneration, but extra-motor …

Aims Intravenous iron therapy can improve symptoms in patients with heart failure, anaemia
and iron deficiency. The mechanisms underlying such an improvement might involve …

Objective To understand the progressive nature of amyotrophic lateral sclerosis (ALS) by
investigating differential brain patterns of gray and white matter involvement in clinically or …

Objective: The aim of this study was to measure both plasma and cerebrospinal fluid (CSF)
TAR DNA-binding protein 43 (TDP-43) and phosphorylated TDP-43 (pTDP-43) levels in …

Bulbar deterioration in amyotrophic lateral sclerosis (ALS) is a devastating characteristic that
impairs patients' ability to communicate, and is linked to shorter survival. The existing clinical …

Astrocytes are major contributors of motor neuron (MN) degeneration in amyotrophic lateral
sclerosis (ALS). We investigated whether regional and cell maturation differences influence …

Objective: To analyze the quality of life (QoL) and frequency of depression in primary
caregivers of patients with amyotrophic lateral sclerosis (ALS) in two neighboring European …

Immunity has emerged as a key player in neurodegenerative diseases such as amyotrophic
lateral sclerosis, with recent studies documenting aberrant immune changes in patients and …

Amyotrophic lateral sclerosis (ALS) patients suffer a great inconvenience in their daily lives
due to the gradual loss of their motion abilities. In order to help ALS patients regain their self …