How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …
preclinical models and emerging evidence in humans have established the crucial roles of …
T cell subsets and functions in atherosclerosis
Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …
Immunotherapy for cardiovascular disease
The outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study
(CANTOS) trial have unequivocally proven that inflammation is a key driver of …
(CANTOS) trial have unequivocally proven that inflammation is a key driver of …
Immune checkpoint inhibitor therapy aggravates T cell–driven plaque inflammation in atherosclerosis
K Poels, MMT van Leent, C Boutros, H Tissot, S Roy… - Cardio Oncology, 2020 - jacc.org
Background Immunotherapy has revolutionized cancer treatment. However, immune
checkpoint inhibitors (ICIs) that target PD-1 (programmed cell death protein-1) and/or CTLA …
checkpoint inhibitors (ICIs) that target PD-1 (programmed cell death protein-1) and/or CTLA …
CD8+ T Cells in Atherosclerosis
S Schäfer, A Zernecke - Cells, 2020 - mdpi.com
Atherosclerotic lesions are populated by cells of the innate and adaptive immune system,
including CD8+ T cells. The CD8+ T cell infiltrate has recently been characterized in mouse …
including CD8+ T cells. The CD8+ T cell infiltrate has recently been characterized in mouse …
Heterogeneity of T cells in atherosclerosis defined by single-cell RNA-sequencing and cytometry by time of flight
The infiltration and accumulation of pro-and anti-inflammatory leukocytes within the intimal
layer of the arterial wall is a hallmark of developing and progressing atherosclerosis. While …
layer of the arterial wall is a hallmark of developing and progressing atherosclerosis. While …
Where the action is—leukocyte recruitment in atherosclerosis
C Mauersberger, J Hinterdobler… - Frontiers in …, 2022 - frontiersin.org
Atherosclerosis is the leading cause of death worldwide and leukocyte recruitment is a key
element of this phenomenon, thus allowing immune cells to enter the arterial wall. There, in …
element of this phenomenon, thus allowing immune cells to enter the arterial wall. There, in …
Identification of biomarkers associated with CD8+ T cells in coronary artery disease and their pan-cancer analysis
S Zhao, Y Wu, Y Wei, X Xu, J Zheng - Frontiers in immunology, 2022 - frontiersin.org
Purpose To identify biomarkers associated with CD8+ T cells in coronary artery disease
(CAD) and initially explore their potential role in the tumor immune microenvironment …
(CAD) and initially explore their potential role in the tumor immune microenvironment …
Inhibition of PFKFB3 hampers the progression of atherosclerosis and promotes plaque stability
K Poels, JG Schnitzler, F Waissi, JHM Levels… - Frontiers in cell and …, 2020 - frontiersin.org
Aims 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase (PFKFB) 3-mediated glycolysis
is pivotal in driving macrophage-and endothelial cell activation and thereby inflammation …
is pivotal in driving macrophage-and endothelial cell activation and thereby inflammation …
Biomimetic nanoparticles targeting atherosclerosis for diagnosis and therapy
Y Li, J Wang, J Xie - Smart Medicine, 2023 - Wiley Online Library
Atherosclerosis is a typical chronic inflammatory vascular disease that seriously endangers
human health. At present, oral lipid‐lowering or anti‐inflammatory drugs are clinically used …
human health. At present, oral lipid‐lowering or anti‐inflammatory drugs are clinically used …