Flexible electronics and devices as human–machine interfaces for medical robotics

W Heng, S Solomon, W Gao - Advanced Materials, 2022 - Wiley Online Library
Medical robots are invaluable players in non‐pharmaceutical treatment of disabilities.
Particularly, using prosthetic and rehabilitation devices with human–machine interfaces can …

The role of BDNF in peripheral nerve regeneration: activity-dependent treatments and Val66Met

CE McGregor, AW English - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Despite the ability of peripheral nerves to spontaneously regenerate after injury, recovery is
generally very poor. The neurotrophins have emerged as an important modulator of axon …

[HTML][HTML] Application of electrical stimulation for peripheral nerve regeneration: Stimulation parameters and future horizons

S Javeed, AH Faraji, C Dy, WZ Ray… - Interdisciplinary …, 2021 - Elsevier
Peripheral nerve trauma impacts both social and occupational quality of life. Patients are
typically young and subsequently suffer from lifelong disability. Unlike the central nervous …

Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury

DI Wu, Y Jin, TM Shapiro, A Hinduja, PW Baas… - Nature …, 2020 - nature.com
After a dorsal root crush injury, centrally-projecting sensory axons fail to regenerate across
the dorsal root entry zone (DREZ) to extend into the spinal cord. We find that chemogenetic …

Functional electrical stimulation and the modulation of the axon regeneration program

JS Jara, S Agger, ER Hollis - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Neural injury in mammals often leads to persistent functional deficits as spontaneous repair
in the peripheral nervous system (PNS) is often incomplete, while endogenous repair …

Advanced materials in wireless, implantable electrical stimulators that offer rapid rates of bioresorption for peripheral axon regeneration

H Guo, D D'Andrea, J Zhao, Y Xu, Z Qiao… - Advanced functional …, 2021 - Wiley Online Library
Injured peripheral nerves typically exhibit unsatisfactory and incomplete functional
outcomes, and there are no clinically approved therapies for improving regeneration. Post …

Angiogenesis is critical for the exercise-mediated enhancement of axon regeneration following peripheral nerve injury

SS Wariyar, AD Brown, T Tian, TS Pottorf… - Experimental …, 2022 - Elsevier
Enhancing axon regeneration is a major focus of nerve injury research, and the quality of the
surgical nerve repair plays a large role in the aggregate success of nerve regeneration …

The median nerve injury model in pre-clinical research–a critical review on benefits and limitations

G Ronchi, M Morano, F Fregnan, P Pugliese… - Frontiers in Cellular …, 2019 - frontiersin.org
The successful introduction of innovative treatment strategies into clinical practise strongly
depends on the availability of effective experimental models and their reliable pre-clinical …

New era of optogenetics: from the central to peripheral nervous system

X Xu, T Mee, X Jia - Critical reviews in biochemistry and molecular …, 2020 - Taylor & Francis
Optogenetics has recently gained recognition as a biological technique to control the activity
of cells using light stimulation. Many studies have applied optogenetics to cell lines in the …

Enhancing motor and sensory axon regeneration after peripheral nerve injury using bioluminescent optogenetics

A Ecanow, K Berglund, D Carrasco, R Isaacson… - International Journal of …, 2022 - mdpi.com
Introduction—Recovery from peripheral nerve injuries is poor even though injured
peripheral axons can regenerate. Novel therapeutic approaches are needed. The most …