Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

Allergic diseases are caused by aberrant T-helper-2 immune responses in susceptible
individuals. Both naturally occurring CD4+ CD25+ regulatory T cells and inducible …

While oral desensitization is capable of alleviating peanut allergen anaphylaxis, long-term
immune tolerance is the sought-after goal. We developed a liver-targeting lipid nanoparticle …

Exposure to inhaled allergens generates T helper 2 (Th2) CD4+ T cells that contribute to
episodes of inflammation associated with asthma. Little is known about allergen-specific Th2 …

The induction of allergen-specific anergy in peripheral T cells represents a key step in
specific immunotherapy (SIT). Here we demonstrate that the anergic state results from …

In parallel with changes in lifestyle over the last 50 years (sedentary living in warm houses
with extensive furnishing and low ventilation rates), there has been a progressive increase …

Allergic diseases mediated by T helper type (Th) 2 cell immune responses are rising
dramatically in most developed countries. Exaggerated Th2 cell reactivity could result, for …

The immunologic specificity of the antigen receptors of T cells and B cells is the result of
random shuffling of the many genes that form the DNA code for the antigen-binding site of …

Specific immune suppression and induction of anergy are essential processes in the
regulation and circumvention of immune defence. Interleukin‐10 (IL‐10), a suppressor …

Orally administered proteins induce systemic hyporesponsiveness to the fed protein. The
mechanism underlying such 'oral tolerance'depends on the amount of antigen fed. with …