Peptide‒drug conjugates (PDCs) are drug delivery systems consisting of a drug covalently
coupled to a multifunctional peptide via a cleavable linker. As an emerging prodrug strategy …

The emergence of peptide–drug conjugates (PDCs) that utilize target-oriented peptide
moieties as carriers of cytotoxic payloads, interconnected with various cleavable …

Acne is a chronic skin condition that has serious consequences for mental and social well-
being because it frequently occurs on the face. Several acne treatment approaches have …

The non-selective cytotoxicity of toxins limits the clinical relevance of the toxins. In recent
years, toxins have been widely used as warheads for antibody‒drug conjugates (ADCs) …

Background Melanoma has the highest mortality rate among all the types of skin cancer. In
melanoma, M2-like tumor-associated macrophages (TAMs) are associated with the …

Glioblastoma multiforme (GBM) is the most common type of glioma, with a median survival of
14.6 months post-diagnosis. Understanding the molecular profile of such tumors allowed the …

With one of the highest mortality rates of all malignancies, the 5-year survival rate for
esophageal cancer is under 20%. Depending on the stage and extent of the disease, the …

The development of peptide drugs has made tremendous progress in the past few decades
because of the advancements in modification chemistry and analytical technologies. The …

Chemotherapy is still one of the main therapeutic approaches in cancer therapy.
Nevertheless, its poor selectivity causes severe toxic side effects that, together with the …