Prostaglandins and inflammation
E Ricciotti, GA FitzGerald - Arteriosclerosis, thrombosis, and …, 2011 - Am Heart Assoc
Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain
homeostatic functions and mediate pathogenic mechanisms, including the inflammatory …
homeostatic functions and mediate pathogenic mechanisms, including the inflammatory …
Nuclear factor-κB—a pivotal transcription factor in chronic inflammatory diseases
In chronic inflammatory diseases, such as asthma, rheumatoid arthritis, inflammatory bowel
disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to …
disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to …
[HTML][HTML] High levels of eicosanoids and docosanoids in the lungs of intubated COVID‐19 patients
Severe acute respiratory syndrome coronavirus 2 is responsible for coronavirus disease
2019 (COVID‐19). While COVID‐19 is often benign, a subset of patients develops severe …
2019 (COVID‐19). While COVID‐19 is often benign, a subset of patients develops severe …
Cyclooxygenases: structural, cellular, and molecular biology
WL Smith, DL DeWitt, RM Garavito - Annual review of …, 2000 - annualreviews.org
▪ Abstract The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also
cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin …
cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin …
Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition
DL Simmons, RM Botting, T Hla - Pharmacological reviews, 2004 - ASPET
Nonsteroidal anti-inflammatory drugs (NSAIDs) represent one of the most highly utilized
classes of pharmaceutical agents in medicine. All NSAIDs act through inhibiting …
classes of pharmaceutical agents in medicine. All NSAIDs act through inhibiting …
Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and− 2
WL Smith, RM Garavito, DL DeWitt - Journal of Biological Chemistry, 1996 - ASBMB
Prostaglandin endoperoxide H synthases (PGHSs) 1 catalyze the conversion of arachidonic
acid and O2 to PGH2, the committed step in prostanoid biosynthesis (Fig. 1)(1). Before 1991 …
acid and O2 to PGH2, the committed step in prostanoid biosynthesis (Fig. 1)(1). Before 1991 …
The coxibs, selective inhibitors of cyclooxygenase-2
GA FitzGerald, C Patrono - New England Journal of Medicine, 2001 - Mass Medical Soc
Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used to treat arthritis, menstrual
pain, and headache. Although they are effective, their long-term use is limited by …
pain, and headache. Although they are effective, their long-term use is limited by …
Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2
BF McAdam, F Catella-Lawson… - Proceedings of the …, 1999 - National Acad Sciences
Prostaglandins (PG) are synthesized by two isoforms of the enzyme PG G/H synthase
[cyclooxygenase (COX)]. To examine selectivity of tolerated doses of an inhibitor of the …
[cyclooxygenase (COX)]. To examine selectivity of tolerated doses of an inhibitor of the …
[HTML][HTML] Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
R Langenbach, SG Morham, HF Tiano, CD Loftin… - Cell, 1995 - cell.com
Abstract Cyclooxygenases 1 and 2 (COX-1 and COX-2) are key enzymes in prostaglandin
biosynthesis and the target enzymes for the widely used nonsteroidal anti-inflammatory …
biosynthesis and the target enzymes for the widely used nonsteroidal anti-inflammatory …
Prostaglandin synthase 2
HR Herschman - Biochimica et Biophysica Acta (BBA)-Lipids and Lipid …, 1996 - Elsevier
'Eicosanoid'is a term coined to describe compounds derived from C 20 fatty acids [1]. The
term is now generally used to identify the paracrine hormones derived from free arachidonic …
term is now generally used to identify the paracrine hormones derived from free arachidonic …