Members of the arginine–serine-rich protein family (SR proteins) are multifunctional RNA-
binding proteins that have emerged as key determinants for mRNP formation, identity and …

Autoimmune diseases (ADs) are chronic pathologies generated by the loss of immune
tolerance to the body's own cells and tissues. There is growing recognition that RNA …

Hypoxia induces massive changes in alternative splicing (AS) to adapt cells to the lack of
oxygen. Here, we identify the splicing factor SRSF6 as a key factor in the AS response to …

With glucose being at the center of energy consumption and production, maintaining
homeostasis of this simple sugar is of pivotal importance. Loss of glucose homeostasis …

Aberrant alternative splicing of pre-mRNA is an emerging cancer hallmark. Many cancer-
associated genes undergo alternative splicing to produce multiple isoforms with diverse or …

Simple Summary Alternative splicing (AS) produces multiple mRNA isoforms from a gene to
make a large number of proteins. Fas (Apo-1/CD95) pre-mRNA, a member of TNF receptor …

Understanding of pancreatic islet biology has greatly increased over the past few decades
based in part on an increased understanding of the transcription factors that guide this …

Completion of the Human Genome Project enabled a novel systems-and network-level
understanding of biology, but this remains to be applied for understanding the pathogenesis …

Serine-and arginine-rich splicing factors are pivotal modulators of constitutive splicing and
alternative splicing that bind to the cis-acting elements in precursor mRNAs and facilitate the …

The family of scaffold attachment factor B (SAFB) proteins comprises three members and
was first identified as binders of the nuclear matrix/scaffold. Over the past two decades …