Pathologies of the brain, of which brain cancer, Alzheimer's disease, Parkinson's disease,
stroke, and multiple sclerosis, are some of the most prevalent, and that presently are poorly …

The cell cycle is a collection of events by which cellular components such as genetic
materials and cytoplasmic components are accurately divided into two daughter cells. The …

Gliomas are the most common type of brain tumor that occur in adults and children.
Glioblastoma multiforme (GBM) is the most common, aggressive form of brain cancer in …

In the present study, we report the design and synthesis of novel CAN508 sulfonamide-
based analogues (4, 8a-e, 9a-h and 10a-e) as novel carbonic anhydrase (CA) inhibitors with …

On account of their overexpression in a wide range of human malignancies, cyclin-
dependent kinases (CDKs) are among the most validated cancer targets, and their inhibition …

Tissue-resident stem cells may enter a dormant state, also known as quiescence, which
allows them to withstand metabolic stress and unfavorable conditions. Similarly, hibernating …

In contrast to preoperative brain tumor segmentation, the problem of postoperative brain
tumor segmentation has been rarely approached so far. We present a fully-automatic …

We examined the expression and pharmacological modulation of the purinergic receptor
P2X7R in a C6 glioma model. Intrastriatal injection of C6 cells induced a time-dependent …

✓ Meningiomas are slow growing, extraaxial tumors that derive from the arachnoidal cap
cells of the meninges. Resection remains the main modality of treatment and can be curative …

Brain tumors remain a significant health problem. Advances in the biology of the blood–
brain barrier are improving the ability of researchers to target therapeutic peptides, small …