Chinese hamster ovary (CHO) cells are the most widely used mammalian host cells for the
commercial production of therapeutic proteins. Fed-batch culture is widely used to produce …

Mass spectrometry (MS) is a powerful technique for protein identification, quantification and
characterization that is widely applied in biochemical studies, and which can provide data …

The emergence of SARS-CoV-2 variants alters the efficacy of existing immunity towards the
viral spike protein, whether acquired from infection or vaccination. Mutations that impact N …

Red blood cells (RBCs) serve as natural transporters and can be modified to enhance the
pharmacokinetics and pharmacodynamics of a protein cargo. Affinity targeting of Factor IX …

Despite widespread advances in DNA sequencing, the functional consequences of most
genetic variants remain poorly understood. Multiplexed Assays of Variant Effect (MAVEs) …

Hemophilia A is an inherited X-linked recessive bleeding disorder that accounts for about
80% of cases of hemophilia, occurs in~ 5 and~ 20 per 100,000 male births, and is caused by …

Hemophilia B or Christmas disease is an X-chromosome-linked recessive bleeding disorder
caused by the deficiency of coagulation factor IX (FIX), with a prevalence of~ 1 per 30,000 …

Appropriate treatment of Hemophilia B is vital for patients' quality of life. Historically, the
treatment used was the administration of coagulation Factor IX derived from human plasma …

Abstract Introduction and Aim: Haemophilia B is an X-linked recessive bleeding disorder
characterised by a deficiency of coagulation factor IX (FIX), due to a wide spectrum of …

Advances in DNA sequencing over the past twenty years have led to an unprecedented
expansion in our ability to read DNA sequences and find genetic variation in individuals …