Invasive Staphylococcus aureus infections are common, causing high mortality,
compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an …

In experimental evolution, laboratory-controlled conditions select for the adaptation of
species, which can be monitored in real time. Despite the current popularity of such …

The rapidly reducing cost of bacterial genome sequencing has lead to its routine use in
large-scale microbial analysis. Though mapping approaches can be used to find differences …

Bacterial virulence is highly dynamic and context-dependent. For this reason, it is
challenging to predict how molecular changes affect the growth of a pathogen in a host and …

Understanding changes in pathogen behavior (eg increased virulence, a shift in
transmission channel) is critical for the public health management of emerging infectious …

Invasive nontyphoidal Salmonella (iNTS) causes extraintestinal infections with~ 15% case
fatality in many countries. However, the mechanism by which iNTS emerged in China …

Nontyphoidal salmonellae (NTS) are a major cause of invasive (iNTS) disease in sub-
Saharan Africa, manifesting as bacteremia and meningitis. Available epidemiological data …

Within-host evolution has resulted in thousands of variants of Salmonella that exhibit
remarkable diversity in host range and disease outcome, from broad host range to exquisite …

During severe infections, Staphylococcus aureus moves from its colonising sites to blood
and tissues and is exposed to new selective pressures, thus, potentially driving adaptive …

Highlights•Genomic signatures of host-adaptation and virulence of Salmonella are
emerging.•Sequence analyses can aid the prediction of zoonotic risk and source …