This review examines the dynamic mechanisms underlying cellular signaling,
communication, and adhesion via transient, nano-scale, liquid-like molecular assemblies on …

G protein‐coupled receptors (GPCRs) are the largest family of transmembrane receptors
and primarily signal through two main effector proteins: G proteins and β‐arrestins. Many …

β-arrestins (βarrs) are multifunctional proteins involved in signaling and regulation of seven
transmembrane receptors (7TMRs), and their interaction is driven primarily by agonist …

Phosphorylated residues of G protein-coupled receptors bind to the N-domain of arrestin,
resulting in the release of its C-terminus. This induces further allosteric conformational …

For many decades, our understanding of G protein-coupled receptor (GPCR) activity and
cyclic AMP (cAMP) signaling was limited exclusively to the plasma membrane. However, a …

Chemokine receptors constitute an important subfamily of G protein-coupled receptors
(GPCRs), and they are critically involved in a broad range of immune response …

G protein-coupled receptors (GPCRs) regulate every aspect of kidney function by mediating
the effects of various endogenous and exogenous substances. A key concept in GPCR …

G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing
signals from the extracellular environment to the inside of the cell. They mediate the effects …

Abstract Phosphatidylinositol 4, 5-bisphosphate (PIP2) has been shown to be critical for the
endocytosis of G protein-coupled receptors (GPCRs). We have previously demonstrated that …

More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that
play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling …