Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

The gut microbiota is essential to health and has recently become a target for live bacterial
cell biotherapies for various chronic diseases including metabolic syndrome, diabetes …

Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …

Acute as well as chronic disorders of the nervous system lead to significant morbidity and
mortality for millions of individuals globally. Given the ability to govern stem cell proliferation …

The insulin/IGF-1 signaling pathway is evolutionarily conserved and its function is mediated
largely by FOXO transcription factors. Reduced insulin/IGF-1 signaling leads to translocation …

During the last three decades, recombinant DNA technology has produced a wide range of
hematopoietic and neurotrophic growth factors, including erythropoietin (EPO), which has …

We report an early-onset autosomal-recessive neurological disease with cerebellar atrophy
and lysosomal dysfunction. We identified bi-allelic loss-of-function (LoF) variants in …

Cognitive impairment (COI) is a prevalent complication across a spectrum of brain disorders,
underpinned by intricate mechanisms yet to be fully elucidated. Neurons, the principal cell …

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, amyotrophic lateral sclerosis, and others, are characterized by …

Life expectancy of individuals in both developed and undeveloped nations continues to rise
at an unprecedented rate. Coupled to this increase in longevity for individuals is the rise in …