CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

Acidosis is a noxious condition associated with inflammation, ischaemia or defective acid
containment. As a consequence, acid sensing has evolved as an important property of …

An increase in CO2/H+ is a major stimulus for increased ventilation and is sensed by
specialized brain stem neurons called central chemosensitive neurons. These neurons …

The carotid body (CB) is an arterial chemoreceptor organ located in the carotid bifurcation
and has a well-recognized role in cardiorespiratory regulation. The CB contains …

Proteins of the CLC gene family assemble to homo-or sometimes heterodimers and either
function as Cl–channels or as Cl–/H+-exchangers. CLC proteins are present in all phyla …

Rationale: Increased sympathetic nerve activity has been linked to the pathogenesis of
hypertension in humans and animal models. Enhanced peripheral chemoreceptor sensitivity …

Walter B. Cannon's research on the sympathetic nervous system and neurochemical
transmission was pioneering. Wisdom has endowed our body with a powerful autonomic …

The carotid body (CB) is a bilateral arterial chemoreceptor located in the carotid artery
bifurcation with an essential role in cardiorespiratory homeostasis. It is composed of highly …

Carotid body chemoreceptors sense hypoxemia, hypercapnia, and acidosis and play an
important role in cardiorespiratory regulation. The molecular mechanism of pH sensing by …

ABSTRACT A debate has raged since the discovery of central and peripheral respiratory
chemoreceptors as to whether the reflexes they mediate combine in an additive (ie, no …