The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

Organoids are powerful models for studying tissue development, physiology, and disease.
However, current culture systems disrupt the inductive tissue-tissue interactions needed for …

Abstract Glucagon-like peptide-1 (GLP-1) controls islet hormone secretion, gut motility, and
body weight, supporting development of GLP-1 receptor agonists (GLP-1RA) for the …

Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …

The blood–brain barrier (BBB) protects the brain and maintains neuronal homeostasis. BBB
properties can vary between brain regions to support regional functions, yet how BBB …

Despite enormous advances, cardiovascular disorders are still a major threat to global
health and are responsible for one-third of deaths worldwide. Research for new therapeutics …

Hypertrophic cardiomyopathy (HCM) is the most common cardiac genetic disorder
characterized by cardiomyocyte hypertrophy and cardiac fibrosis. Pathological cardiac …

Human pluripotent stem cell (hPSC)-derived intestinal organoids (HIOs) lack some cellular
populations found in the native organ, including vasculature. Using single-cell RNA …

Ischemic cardiomyopathy (ICM) is the leading cause of heart failure worldwide, yet the
cellular and molecular signature of this disease is largely unclear. Using single-nucleus …