Cardiac arrhythmias can cause sudden cardiac death (SCD) and add to the current heart
failure (HF) health crisis. Nevertheless, the pathological processes underlying arrhythmias …

Background: Cardiac arrhythmias represent a significant problem globally, leading to
cerebrovascular accidents, myocardial infarction, and sudden cardiac death. There is …

We compared the effect n-3 polyunsaturated fatty acids (PUFAs) with direct renin inhibition
on electrophysiological remodeling in angiotensin II–induced cardiac injury. We treated …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

The role of the renin-angiotensin-aldosterone system (RAAS) in many cardiovascular
disorders, including hypertension, cardiac hypertrophy, and atherosclerosis, is well …

Rationale: Remodeling of connexin (Cx) 43 gap junctions (GJs) is linked to ventricular
arrhythmia. Objectives: A peptide mimetic of the carboxyl terminal (CT) of Cx43 …

Background—Previously, we showed that a mouse model (ACE8/8) of cardiac renin–
angiotensin system activation has a high rate of spontaneous ventricular tachycardia and …

Connexin-43 (Cx43) gap junctions provide intercellular coupling, which ensures rapid action
potential propagation and synchronized heart contraction. Alterations in Cx43 localization …

The voltage-gated Na channel isoform 1.5 (NaV1. 5) is the pore forming α-subunit of the
voltage-gated cardiac Na channel, which is responsible for the initiation and propagation of …

Objectives: The aim of this study was to test whether c-Src tyrosine kinase mediates
connexin-43 (Cx43) reduction and sudden cardiac death in a transgenic mouse model of …