A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases

S He, J Gui, K Xiong, M Chen, H Gao, Y Fu - Journal of nanobiotechnology, 2022 - Springer
Pulmonary drug delivery is a highly attractive topic for the treatment of infectious lung
diseases. Drug delivery via the pulmonary route offers unique advantages of no first-pass …

The pathological maelstrom of COVID-19 and cardiovascular disease

M Giacca, AM Shah - Nature Cardiovascular Research, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a consequence of infection of the upper
and lower respiratory tract with severe acute respiratory syndrome coronavirus 2 but often …

Microgliosis and neuronal proteinopathy in brain persist beyond viral clearance in SARS-CoV-2 hamster model

C Käufer, CS Schreiber, AS Hartke, I Denden… - …, 2022 - thelancet.com
Background Neurological symptoms such as cognitive decline and depression contribute
substantially to post-COVID-19 syndrome, defined as lasting symptoms several weeks after …

SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

CM Lieber, RM Cox, J Sourimant, JD Wolf… - Nature …, 2022 - nature.com
SARS-CoV-2 variants of concern (VOC) have triggered infection waves. Oral antivirals such
as molnupiravir promise to improve disease management, but efficacy against VOC delta …

Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection

M Ferren, V Favède, D Decimo, M Iampietro… - Nature …, 2021 - nature.com
SARS-CoV-2 has caused a global pandemic of COVID-19 since its emergence in December
2019. The infection causes a severe acute respiratory syndrome and may also spread to …

Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2

MF Tioni, R Jordan, AS Pena, A Garg, D Wu, SI Phan… - npj Vaccines, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the COVID-19 global pandemic. SARS-CoV-2 is an enveloped RNA virus that relies on its …

Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections

PYA Reinke, EE de Souza, S Günther, S Falke… - Communications …, 2023 - nature.com
Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-
CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro …

Bovine lactoferrin inhibits SARS‐CoV‐2 and SARS‐CoV‐1 by targeting the RdRp complex and alleviates viral infection in the hamster model

S He, H Qin, L Guan, K Liu, B Hong… - Journal of Medical …, 2023 - Wiley Online Library
Breast milk has been found to inhibit coronavirus infection, while the key components and
mechanisms are unknown. We aimed to determine the components that contribute to the …

SARS-CoV-2 bearing a mutation at the S1/S2 cleavage site exhibits attenuated virulence and confers protective immunity

M Sasaki, S Toba, Y Itakura, HM Chambaro… - Mbio, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) possesses a
discriminative polybasic cleavage motif in its spike protein that is recognized by the host …

Therapeutic potential of melatonin and melatonergic drugs on K18‐hACE2 mice infected with SARS‐CoV‐2

E Cecon, C Izabelle, SL Poder, F Real… - Journal of Pineal …, 2022 - Wiley Online Library
As the COVID‐19 pandemic grows, several therapeutic candidates are being tested or
undergoing clinical trials. Although prophylactic vaccination against SARS‐CoV‐2 infection …