Data-driven multiscale computational models of cortical and subcortical regions

S Ramaswamy - Current opinion in neurobiology, 2024 - Elsevier
Data-driven computational models of neurons, synapses, microcircuits, and mesocircuits
have become essential tools in modern brain research. The goal of these multiscale models …

[HTML][HTML] Recent data on the cerebellum require new models and theories

Y Zang, E De Schutter - Current Opinion in Neurobiology, 2023 - Elsevier
The cerebellum has been a popular topic for theoretical studies because its structure was
thought to be simple. Since David Marr and James Albus related its function to motor skill …

A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics

RM Lorenzi, A Geminiani, Y Zerlaut… - PLOS Computational …, 2023 - journals.plos.org
Mean-field (MF) models are computational formalism used to summarize in a few statistical
parameters the salient biophysical properties of an inter-wired neuronal network. Their …

Variations on the theme: focus on cerebellum and emotional processing

C Ciapponi, Y Li, DA Osorio Becerra… - Frontiers in Systems …, 2023 - frontiersin.org
The cerebellum operates exploiting a complex modular organization and a unified
computational algorithm adapted to different behavioral contexts. Recent observations …

Cerebellar Functions Beyond Movement and Learning

LH Kim, DH Heck, RV Sillitoe - Annual Review of Neuroscience, 2024 - annualreviews.org
The cerebellum has a well-established role in controlling motor functions, including
coordination, posture, and the learning of skilled movements. The mechanisms for how it …

Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity

S Masoli, D Sanchez-Ponce, N Vrieler… - Communications …, 2024 - nature.com
Purkinje cells in the cerebellum are among the largest neurons in the brain and have been
extensively investigated in rodents. However, their morphological and physiological …

Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons

V Takács, Z Bardóczi, Á Orosz, A Major, L Tar… - Plos …, 2024 - journals.plos.org
GABAergic inhibitory neurons fundamentally shape the activity and plasticity of cortical
circuits. A major subset of these neurons contains somatostatin (SOM); these cells play …

New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment

P Faris, D Pischedda, F Palesi… - Frontiers in Cellular …, 2024 - frontiersin.org
Schizophrenia (SZ) is a complex neuropsychiatric disorder associated with severe cognitive
dysfunction. Although research has mainly focused on forebrain abnormalities, emerging …

Advancements in Cerebellar Modeling and its Practical Applications: A Comprehensive Review

S Huang, T Xu, J Chen, J Huang, Z Wang, Y Ke… - IEEE …, 2024 - ieeexplore.ieee.org
The cerebellum plays a crucial role in motor learning and memory, and recent studies have
proposed various cerebellar models to investigate these functions. This review examines the …

A multi-layer mean-field model for the cerebellar cortex: design, validation, and prediction

RM Lorenzi, A Geminiani, Y Zerlaut, A Destexhe… - bioRxiv, 2022 - biorxiv.org
Mean-field (MF) models can be used to summarize in a few statistical parameters the salient
properties of an inter-wired neuronal network incorporating different types of neurons and …