Reactive oxygen species (ROS) are reactive intermediates of molecular oxygen that act as
important second messengers within the cells; however, an imbalance between generation …

Clinical and experimental data support a link between endothelial dysfunction and
inflammation. Inflammatory cytokines are important protagonists in formation of …

TNFα is crucially involved in the pathogenesis and progression of atherosclerosis,
myocardial ischemia/reperfusion injury and heart failure. The formation and release of TNFα …

Coronary microvascular disease (CMD), which affects the arterioles and capillary
endothelium that regulate myocardial perfusion, is an increasingly recognized source of …

The transient receptor potential vallinoid type 4 (TRPV4) channel has been implicated in the
endothelial shear response and flow-mediated dilation, although the precise functions of this …

Inflammation is a condition that underscores many cardiovascular pathologies including
endothelial dysfunction, but no link is yet established between the vascular pathology of the …

Cellular activation involves the re-organization of receptor molecules and the intracellular
signalosom in the cell membrane. Recent studies indicate that specialized domains of the …

Background—We hypothesized that the inflammatory cytokine tumor necrosis factor-α (TNF)
produces endothelial dysfunction in type 2 diabetes. Methods and Results—In m Leprdb …

Activation of cells by receptor-and nonreceptor-mediated stimuli not only requires a change
in the activity of signaling proteins but also requires a reorganization of the topology of the …

Agonist-induced Ca2+ entry is important for the synthesis and release of vasoactive factors
in endothelial cells. The transient receptor potential vanilloid type 4 (TRPV4) channel, a …