Treg enhancing therapies to treat autoimmune diseases

PJ Eggenhuizen, BH Ng, JD Ooi - International journal of molecular …, 2020 - mdpi.com
Regulatory T cells (Tregs) are a small yet critical subset of CD4+ T cells, which have the role
of maintaining immune homeostasis by, for example, regulating self-tolerance, tumor …

Immune checkpoints and their inhibition in cancer and infectious diseases

L Dyck, KHG Mills - European journal of immunology, 2017 - Wiley Online Library
The development of chronic infections and cancer is facilitated by a variety of immune
subversion mechanisms, such as the production of anti‐inflammatory cytokines, induction of …

Th17 and regulatory T cell balance in autoimmune and inflammatory diseases

M Noack, P Miossec - Autoimmunity reviews, 2014 - Elsevier
This review focuses on the biology of T helper 17 (Th17) and regulatory T (Treg) cells and
their role in inflammatory diseases, such as rheumatoid arthritis. Th17 cells represent a pro …

A global perspective on hantavirus ecology, epidemiology, and disease

CB Jonsson, LTM Figueiredo… - Clinical microbiology …, 2010 - Am Soc Microbiol
Hantaviruses are enzootic viruses that maintain persistent infections in their rodent hosts
without apparent disease symptoms. The spillover of these viruses to humans can lead to …

[HTML][HTML] An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system

SK Mazmanian, CH Liu, AO Tzianabos, DL Kasper - Cell, 2005 - cell.com
The mammalian gastrointestinal tract harbors a complex ecosystem consisting of countless
bacteria in homeostasis with the host immune system. Shaped by evolution, this partnership …

IL-10: the master regulator of immunity to infection

KN Couper, DG Blount, EM Riley - The Journal of Immunology, 2008 - journals.aai.org
IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK
cells, and macrophages, all of which are required for optimal pathogen clearance but also …

Immunity, tolerance and autoimmunity in the liver: A comprehensive review

DG Doherty - Journal of autoimmunity, 2016 - Elsevier
The hepatic immune system is constantly exposed to a massive load of harmless dietary and
commensal antigens, to which it must remain tolerant. Immune tolerance in the liver is …

Dengue in india

N Gupta, S Srivastava, A Jain… - Indian Journal of …, 2012 - journals.lww.com
Dengue virus belongs to family Flaviviridae, having four serotypes that spread by the bite of
infected Aedes mosquitoes. It causes a wide spectrum of illness from mild asymptomatic …

Regulatory T cell-derived extracellular vesicles modify dendritic cell function

SL Tung, DA Boardman, M Sen, M Letizia, Q Peng… - Scientific Reports, 2018 - nature.com
Regulatory T cells (Treg) are a subpopulation of T cells that maintain tolerance to self and
limit other immune responses. They achieve this through different mechanisms including the …

Mesenchymal stem cells avoid allogeneic rejection

JM Ryan, FP Barry, JM Murphy, BP Mahon - Journal of inflammation, 2005 - Springer
Adult bone marrow derived mesenchymal stem cells offer the potential to open a new
frontier in medicine. Regenerative medicine aims to replace effete cells in a broad range of …