The role of inflammation in the development of epilepsy

A Rana, AE Musto - Journal of neuroinflammation, 2018 - Springer
Epilepsy, a neurological disease characterized by recurrent seizures, is often associated
with a history of previous lesions in the nervous system. Impaired regulation of the activation …

Neuron–glia interactions in the pathophysiology of epilepsy

DC Patel, BP Tewari, L Chaunsali… - Nature Reviews …, 2019 - nature.com
Epilepsy is a neurological disorder afflicting~ 65 million people worldwide. It is caused by
aberrant synchronized firing of populations of neurons primarily due to imbalance between …

Potential therapeutic application of chondroitin sulfate/dermatan sulfate

S Yamada, K Sugahara - Current Drug Discovery Technologies, 2008 - ingentaconnect.com
Glycosaminoglycans (GAGs) are complex polysaccharides, which play important roles in
cell growth, differentiation, morphogenesis, cell migration, and bacterial/viral infections …

[HTML][HTML] The pilocarpine model of epilepsy: what have we learned?

FA Scorza, RM Arida… - Anais da Academia …, 2009 - SciELO Brasil
The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes
sequential behavioral and electrographic changes that can be divided into 3 distinct …

Integrins as receptor targets for neurological disorders

X Wu, DS Reddy - Pharmacology & therapeutics, 2012 - Elsevier
This review focuses on the neurobiology of integrins, pathophysiological roles of integrins in
neuroplasticity and nervous system disorders, and therapeutic implications of integrins as …

Extracellular matrix components associated with remodeling processes in brain

U Rauch - Cellular and Molecular Life Sciences CMLS, 2004 - Springer
In the central nervous system, various extracellular matrix components have been identified
which are strongly expressed during development and in most areas of the brain down …

The perineuronal net component of the extracellular matrix in plasticity and epilepsy

PA McRae, BE Porter - Neurochemistry international, 2012 - Elsevier
During development the extracellular matrix (ECM) of the central nervous system (CNS)
facilitates proliferation, migration, and synaptogenesis. In the mature nervous system due to …

[HTML][HTML] Inflammatory and immune mechanisms underlying epileptogenesis and epilepsy: From pathogenesis to treatment target

I Mukhtar - Seizure, 2020 - Elsevier
Epilepsy is a brain disease associated with epileptic seizures as well as with
neurobehavioral outcomes of this condition. In the last century, inflammation emerged as a …

Glutamate and astrocytes—key players in human mesial temporal lobe epilepsy?

T Eid, A Williamson, TSW Lee, OA Petroff… - …, 2008 - Wiley Online Library
Approximately one‐third of all patients with epilepsy continue to suffer from seizures even
after appropriate treatment with antiepileptic drugs. Medically refractory epilepsies are …

Berberine-loaded zein/hyaluronic acid composite nanoparticles for efficient brain uptake to alleviate neuro-degeneration in the pilocarpine model of epilepsy

AE El-Nahas, HM Elbedaiwy, IM Masoud… - European Journal of …, 2023 - Elsevier
Berberine hydrochloride is a plant alkaloid with versatile medicinal applications, yet it has
suffered from multiple limitations in its usage. Nonetheless, the acknowledged role of …