Utilization of polymers as biomaterials has greatly impacted the advancement of modern
medicine. Specifically, polymeric biomaterials that are biodegradable provide the significant …

Biodegradable polymers have been used in biomedical applications generally, and in tissue
engineering especially, due to good physical and biological properties. Poly …

Tumor necrosis factor-α (TNF-α) plays an essential role in the regulation of bone
homeostasis in several chronic immune and inflammatory joint diseases, where inhibition of …

The pronounced biological influence of the tumor microenvironment on cancer progression
and metastasis has gained increased recognition over the past decade, yet most preclinical …

Inflammation is an immediate response that plays a critical role in healing after fracture or
injury to bone. However, in certain clinical contexts, such as in inflammatory diseases or in …

Objectives: To investigate tumor necrosis factor alpha (TNF‐α)‐induced changes in
osteogenic differentiation from mesenchymal stem cells (MSCs). Materials and methods …

The mechanism by which trauma initiates healing remains unclear. Precise understanding
of these events may define interventions for accelerating healing that could be translated to …

Abstract Background Mesenchymal stem cells (MSCs) are capable of immunomodulation
and tissue regeneration, highlighting their potential translational application for treating …

Inflammation is a defensive mechanism for pathogen clearance and maintaining tissue
homeostasis. In the skeletal system, inflammation is closely associated with many bone …

Objectives: Rheumatoid arthritis (RA) is characterized by defective bone repair and
excessive destruction and ankylosing spondylitis (AS) by increased ectopic bone formation …