Methylxanthine is a high-value derivative of caffeine of limited natural availability with many
potential pharmaceutical applications. Unfortunately, production of 1-methylxanthine …

One of the helpful ways to improve the effectiveness of anticancer agents and weaken drug
resistance is to use hybrid molecules. therefore, the current study intended to introduce 20 …

Fused pyrimidines scaffolds such as pyrimidopyrimidines, purines and xanthines are
important structural motifs found in various natural products and drug molecules. They are …

A series of novel xanthine/NO donor hybrids containing 1, 3, 8-trisubstituted or 1, 8-
disubstituted xanthine derivatives were designed and synthesized. The synthesized …

A new series of 1-alkyl-8-(piperazine-1-sulfonyl) phenylxanthines was designed,
synthesized, and characterized in radioligand binding and functional assays at A2B …

Water-soluble prodrugs of potent, A2A-selective adenosine receptor (AR) antagonists were
prepared. 8-(m-Bromostyryl)-3, 7-dimethyl-1-propargylxanthine (BS-DMPX, 11) and the …

3-Unsubstituted xanthine derivatives bearing a cyclopentyl or a phenyl residue in the 8-
position were synthesized and developed as A2B adenosine receptor antagonists …

The functionalization of the skeletal systems of heterocycles represents a significant goal for
the development of new compounds. The heterocyclic molecule xanthine (3, 7-dihydro …

A series of 8-substituted derivatives of 3, 7-dimethyl-1-propargylxanthine (DMPX) was
synthesized and investigated as A2A adenosine receptor antagonists. Different synthetic …

The MAS-related Gq protein-coupled receptor X4 (MRGPRX4) is poorly investigated.
MRGPRX4 has been proposed to be involved in pain transmission, itch, inflammation …