Youth-onset type 2 diabetes: the epidemiology of an awakening epidemic

W Perng, R Conway, E Mayer-Davis… - Diabetes Care, 2023 - Am Diabetes Assoc
In this narrative review, we describe the epidemiology (prevalence, incidence, temporal
trends, and projections) of type 2 diabetes among children and adolescents (< 20 years) …

Gestational diabetes: Implications for fetal growth, intervention timing, and treatment options

M Mirabelli, E Chiefari, V Tocci, E Greco, D Foti… - Current Opinion in …, 2021 - Elsevier
Maternal gestational diabetes mellitus (GDM) is one of the most common medical
complications of pregnancy, which can adversely affect the short-and long-term health of …

Precision Interventions Targeting the Maternal Metabolic Milieu for Healthy Pregnancies in Obesity

AM Niclou, HE Cabre, EW Flanagan… - Current Diabetes …, 2024 - Springer
Abstract Purpose of Review Entering pregnancy with obesity increases the risk of adverse
health outcomes for parent and child. As such, research interventions are largely focused on …

[HTML][HTML] Maternal serum metabolomics in mid-pregnancy identifies lipid pathways as a key link to offspring obesity in early childhood

EC Francis, K Kechris, RK Johnson, S Rawal… - International journal of …, 2024 - mdpi.com
Maternal metabolism during pregnancy shapes offspring health via in utero programming. In
the Healthy Start study, we identified five subgroups of pregnant women based on …

Novel metabolic subtypes in pregnant women and risk of early childhood obesity in offspring

EC Francis, K Kechris, T Jansson, D Dabelea… - JAMA Network …, 2023 - jamanetwork.com
Importance The in utero metabolic milieu is associated with offspring adiposity. Standard
definitions of maternal obesity (according to prepregnancy body mass index [BMI]) and …

Maternal glucose intolerance during pregnancy affects offspring POMC expression and results in adult metabolic alterations in a sex-dependent manner

MG Martins, Z Silver, K Ayoub, L Hyland… - Frontiers in …, 2023 - frontiersin.org
Introduction Gestational diabetes (GDM) is associated with negative outcomes in mothers
and their offspring, including greater risks of macrosomia at birth and the development of …

Identification of the Inner Cell Mass and the Trophectoderm Responses after an In Vitro Exposure to Glucose and Insulin during the Preimplantation Period in the …

R Via y Rada, N Daniel, C Archilla, A Frambourg… - Cells, 2022 - mdpi.com
The prevalence of metabolic diseases is increasing, leading to more women entering
pregnancy with alterations in the glucose-insulin axis. The aim of this work was to …

Endotoxin biomarkers are associated with adiposity and cardiometabolic risk across 6 years of follow-up in youth

W Perng, JE Friedman, RC Janssen… - The Journal of …, 2022 - academic.oup.com
Context Metabolic endotoxemia may be a shared mechanism underlying childhood obesity
and early-onset metabolic diseases (eg, type 2 diabetes, nonalcoholic fatty liver disease) …

[HTML][HTML] Glucose and oxygen in the early intrauterine environment and their role in developmental abnormalities

A Hufnagel, ID Grant, CEM Aiken - Seminars In Cell & Developmental …, 2022 - Elsevier
The early life environment can have profound impacts on the developing conceptus in terms
of both growth and morphogenesis. These impacts can manifest in a variety of ways …

Effects of maternal mild hyperglycemia associated with snack intake on offspring metabolism and behavior across the lifespan

MG Martins, B Woodside, ACI Kiss - Physiology & Behavior, 2024 - Elsevier
The increasing prevalence of diabetes is of particular concern in women of childbearing age
because of the short and long-term consequences of maternal diabetes for the health of the …