Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

The avermectins and milbemycins contain a common macrocyclic lactone (ML) ring, but are
fermentation products of different organisms. The principal structural difference is that …

P-glycoprotein (P-gp) is involved in the ATP-dependant cellular efflux of a large number of
drugs including ivermectin, a macrocyclic lactone (ML) endectocide, widely used in livestock …

Salinomycin, a polyether antibiotic acting as a highly selective potassium ionophore and
widely used as an anticoccidial drug, was recently shown to act as a specific inhibitor of …

The benefits of plant polyphenols as chemotherapeutic agents are of great interest due to
their possible anti-cancerogenic activities. Results available up to now suggest that …

Several obstacles are currently impeding the successful treatment of breast cancer, namely
impaired drug accumulation into the tumor site, toxicity to normal cells and narrow …

Background Sodium hyaluronate (SH) is used in patients with dry eye. We evaluated the
efficacy and safety of SH and carboxymethylcellulose (CMC) in the treatment of dry eye …

The most frequent drawback of doxorubicin is the onset of drug resistance, due to the active
efflux through P-glycoprotein (Pgp). Recently formulations of liposome-encapsulated …

P-glycoprotein (Pgp), coded for by the mdr1 gene, is one of the ABC transporters held
responsible for the phenomenon of multidrug resistance (mdr), which is reflected by a …

With an aim to generate non-toxic, specific and highly potent multidrug resistance (MDR)
modulators, a novel series of anthranilic acid amide-substituted tariquidar derivatives were …