Exploiting unique features of microneedles to modulate immunity

C Edwards, SA Shah, T Gebhardt… - Advanced …, 2023 - Wiley Online Library
Microneedle arrays (MNAs) are small patches containing hundreds of short projections that
deliver signals directly to dermal layers without causing pain. These technologies are of …

Responsive microneedles as a new platform for precision immunotherapy

X Liu, H Song, T Sun, H Wang - Pharmaceutics, 2023 - mdpi.com
Microneedles are a well-known transdermal or transdermal drug delivery system. Different
from intramuscular injection, intravenous injection, etc., the microneedle delivery system …

Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer

SK Alsaiari, S Nadeef, JL Daristotle, W Rothwell… - Science …, 2024 - science.org
Nanomaterials offer unique opportunities to engineer immunomodulatory activity. In this
work, we report the Toll-like receptor agonist activity of a nanoscale adjuvant zeolitic …

STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury

J Ni, T Guo, Y Zhou, S Jiang, L Zhang, Z Zhu - Journal of Translational …, 2023 - Springer
Background Radiation-induced lung injury (RILI) is a prevalent complication of thoracic
radiotherapy in cancer patients. A comprehensive understanding of the underlying …

Click‐Chemistry‐Mediated Cell Membrane Glycopolymer Engineering to Potentiate Dendritic Cell Vaccines

H Yang, Z Xiong, X Heng, X Niu, Y Wang… - Angewandte …, 2024 - Wiley Online Library
Dendritic cell vaccine (DCV) holds great potential in tumor immunotherapy owing to its
potent ability in eliciting tumor‐specific immune responses. Aiming at engineering enhanced …

From conventional to cutting-edge: Exosomes revolutionizing nano-drug delivery systems

H Fu, Y Chen, Q Fu, Q Lv, J Zhang, Y Yang… - Chemical Engineering …, 2024 - Elsevier
To address challenges encountered by conventional drug delivery systems (DDS) such as
easy degradation, poor utilization, and low loading rates, researchers have been …

cGAS/STING in skin melanoma: from molecular mechanisms to therapeutics

J Mahin, X Xu, L Li, C Zhang - Cell Communication and Signaling, 2024 - Springer
Melanoma, recognized as the most aggressive type of skin cancer, has experienced a
notable increase in cases, especially within populations with fair skin. This highly aggressive …

Tuning innate immune function using microneedles containing multiple classes of toll-like receptor agonists

C Edwards, RS Oakes, CM Jewell - Nanoscale, 2023 - pubs.rsc.org
Microneedle arrays (MNAs) are patches displaying hundreds of micron-scale needles that
can penetrate skin. As a result, these arrays efficiently and painlessly access this immune …

Harnessing biomaterial architecture to drive anticancer innate immunity

MA Davis, E Cho, MH Teplensky - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Immunomodulation is a powerful therapeutic approach that harnesses the body's own
immune system and reprograms it to treat diseases, such as cancer. Innate immunity is key …

Engineered Immune Constructs Alter Antigen-Specific Immune Tolerance and Confer Durable Protection in Myelin-Driven Autoimmunity

MA Ackun-Farmmer, M Willson Shirkey, RS Oakes… - ACS …, 2024 - ACS Publications
Autoimmune diseases are broadly characterized as a failure in immune tolerance. In
multiple sclerosis (MS), autoreactive immune cells attack the protective myelin sheath lining …