Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Ziconotide (PRIALT®) is a neuroactive peptide in the final stages of clinical development as
a novel non-opioid treatment for severe chronic pain. It is the synthetic equivalent of ω …

The adult brain is extremely vulnerable to various insults. The recent discovery of neural
progenitors in adult mammals, however, raises the possibility of repairing damaged tissue …

Background—Neuroprotective drugs for acute stroke have appeared to work in animals,
only to fail when tested in humans. With the failure of so many clinical trials, the future of …

We search for ischemic stroke treatment knowing we have failed—intensely and often—to
translate mechanistic knowledge into treatments that alleviate our patients' functional …

Previous attempts to identify neuroprotective targets by studying the ischemic cascade and
devising ways to suppress it have failed to translate to efficacious therapies for acute …

Increasing evidence demonstrates that oxidative stress plays an important role in brain
injury in experimental models of brain ischemia. Thymoquinone, the main constituents of the …

The possibility that hypothermia during or after resuscitation from asphyxia at birth, or
cardiac arrest in adults, might reduce evolving damage has tantalized clinicians for a very …

It has long been accepted that high concentrations of glutamate can destroy neurons, and
this is the basis of the theory of excitotoxicity during brain injury such as stroke. Glutamate N …

The hippocampal CA1 neurons are selectively vulnerable to global ischemia, and neuronal
death occurs in a delayed manner. The threshold of global ischemia duration that induces …