GP Miljanich - Current medicinal chemistry, 2004 - ingentaconnect.com
Ziconotide (PRIALT®) is a neuroactive peptide in the final stages of clinical development as a novel non-opioid treatment for severe chronic pain. It is the synthetic equivalent of ω …
H Nakatomi, T Kuriu, S Okabe, S Yamamoto, O Hatano… - Cell, 2002 - cell.com
The adult brain is extremely vulnerable to various insults. The recent discovery of neural progenitors in adult mammals, however, raises the possibility of repairing damaged tissue …
Background—Neuroprotective drugs for acute stroke have appeared to work in animals, only to fail when tested in humans. With the failure of so many clinical trials, the future of …
We search for ischemic stroke treatment knowing we have failed—intensely and often—to translate mechanistic knowledge into treatments that alleviate our patients' functional …
M Papadakis, G Hadley, M Xilouri, LC Hoyte, S Nagel… - Nature medicine, 2013 - nature.com
Previous attempts to identify neuroprotective targets by studying the ischemic cascade and devising ways to suppress it have failed to translate to efficacious therapies for acute …
AA Al-Majed, FA Al-Omar, MN Nagi - European journal of pharmacology, 2006 - Elsevier
Increasing evidence demonstrates that oxidative stress plays an important role in brain injury in experimental models of brain ischemia. Thymoquinone, the main constituents of the …
The possibility that hypothermia during or after resuscitation from asphyxia at birth, or cardiac arrest in adults, might reduce evolving damage has tantalized clinicians for a very …
L Hoyte, PA Barber, AM Buchan… - Current molecular …, 2004 - ingentaconnect.com
It has long been accepted that high concentrations of glutamate can destroy neurons, and this is the basis of the theory of excitotoxicity during brain injury such as stroke. Glutamate N …
T Sugawara, A Lewén, N Noshita, Y Gasche… - Journal of …, 2002 - liebertpub.com
The hippocampal CA1 neurons are selectively vulnerable to global ischemia, and neuronal death occurs in a delayed manner. The threshold of global ischemia duration that induces …