Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus

SR Salpeter, E Greyber, GA Pasternak… - … of systematic reviews, 2010 - cochranelibrary.com
Background Metformin is an oral anti‐hyperglycemic agent that has been shown to reduce
total mortality compared to other anti‐hyperglycemic agents, in the treatment of type 2 …

Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis

R Jayawardena, P Ranasinghe, P Galappatthy… - Diabetology & metabolic …, 2012 - Springer
The number of people with diabetes and pre-diabetes are exponentially increasing. Studies
on humans have shown the beneficial effects of Zinc supplementation in patients with …

The role of zinc and copper in insulin resistance and diabetes mellitus

G Bjørklund, M Dadar, L Pivina… - Current medicinal …, 2020 - ingentaconnect.com
The prevalence of Type 2 Diabetes Mellitus (T2DM) is internationally ever-growing.
Therefore, prevention, diagnostics, and control of insulin resistance and T2DM are of …

[HTML][HTML] Melatonin and the ovary: physiological and pathophysiological implications

H Tamura, Y Nakamura, A Korkmaz, LC Manchester… - Fertility and sterility, 2009 - Elsevier
OBJECTIVE: To summarize the role of melatonin in the physiology and pathophysiology of
the ovary. DESIGN: Review of literature. SETTING: University Health Science Center …

[HTML][HTML] Zinc supplementation improves glycemic control for diabetes prevention and management: a systematic review and meta-analysis of randomized controlled …

X Wang, W Wu, W Zheng, X Fang, L Chen… - The American journal of …, 2019 - Elsevier
Background Although many studies have shown that low zinc status is associated with
diabetes, the putative effects of zinc supplementation on glycemic control are inconclusive …

How effective are antioxidant supplements in obesity and diabetes?

D Abdali, SE Samson, AK Grover - Medical Principles and Practice, 2015 - karger.com
Obesity is a central health issue due to its epidemic prevalence and its association with type
2 diabetes and other comorbidities. Obesity is not just being overweight. It is a metabolic …

Clinical uses of melatonin: evaluation of human trials

EJ Sánchez-Barceló, MD Mediavilla… - Current medicinal …, 2010 - ingentaconnect.com
During the last 20 years, numerous clinical trials have examined the therapeutic usefulness
of melatonin in different fields of medicine. The objective of this article is to review, in depth …

Melatonin, endocrine pancreas and diabetes

E Peschke - Journal of pineal research, 2008 - Wiley Online Library
Melatonin influences insulin secretion both in vivo and in vitro.(i) The effects are MT1‐and
MT2‐receptor‐mediated.(ii) They are specific, high‐affinity, pertussis‐toxin‐sensitive, Gi …

Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening

P Rubio-Sastre, FAJL Scheer, P Gómez-Abellán… - Sleep, 2014 - academic.oup.com
Abstract Study Objectives: To study the effect of melatonin administration on glucose
metabolism in humans in the morning and evening. Design: Placebo-controlled, single-blind …

Inflammaging, metabolic syndrome and melatonin: a call for treatment studies

DP Cardinali, R Hardeland - Neuroendocrinology, 2017 - karger.com
The metabolic syndrome (MS) is a collection of risk factors for cardiovascular disease,
including obesity, hypertension, hyperinsulinemia, glucose intolerance and dyslipidemia …