The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

In addition to their intracellular mobility, mitochondria and their components can exist
outside the cells from which they originate. As a result, they are capable of acting on non …

There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …

Abstract Purpose of Review Mitochondria play various roles that are important for cell
function and survival; therefore, significant mitochondrial dysfunction may have chronic …

Cold static preservation on ice (~ 4° C) remains the clinical standard of donor organ
preservation. However, mitochondrial injury develops during prolonged storage, which limits …

Body fluids are constantly replenished with a population of genetically diverse cell-free DNA
(cfDNA) fragments, representing a vast reservoir of information reflecting real-time changes …

Cigarette smoking is a major risk factor for atherosclerosis. We previously reported that DNA
damage was accumulated in atherosclerotic plaque, and was increased in human …

Mitochondria sense both biochemical and energetic input in addition to communicating
signals regarding the energetic state of the cell. Increasingly, these signaling organelles are …