Background An assessment of the correlation between anti-malarial treatment outcome and
molecular markers would improve the early detection and monitoring of drug resistance by …

Over the past six decades, the drug resistance of Plasmodium falciparum has become an
issue of utmost concern. Despite the remarkable progress that has been made in recent …

The contribution of underdosing to antimalarial treatment failure has been
underappreciated. Most recommended dosage regimens are based on studies in non …

Background Achieving adequate antimalarial drug exposure is essential for curing malaria.
Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug …

Background Mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase
(dhps) genes of Plasmodium falciparum are associated with resistance to anti-folate drugs …

Among the various determinants of treatment response, the achievement of sufficient blood
levels is essential for curing malaria. For helping us at improving our current understanding …

Host immunity is an important but poorly understood determinant of antimalarial efficacy,
influencing the outcome of prevention and treatment trials. Variations in host immunity might …

Background Despite substantial improvement in the control of malaria and decreased
prevalence of malnutrition over the past two decades, both conditions remain heavy burdens …

One of the greatest obstacles to the control of malaria has been the spread of resistance to
drugs used on a large scale. This review provides an update of the current understanding of …

In epidemiological studies, antimalarials measurements in blood represent the best
available marker of drugs exposure at population level, an important driver for the …