Curcumin, the natural yellow‐colored active principle, also called turmeric yellow, extracted
from the perennial herb Curcuma longa L., has potent biological and pharmacological …

Astrocytes are the most abundant glial cells in the central nervous system, and are important
players in both brain injury and neurodegenerative disease. Curcumin (1, 7-bis [4-hydroxy-3 …

Mitochondria are dynamic double-membrane bound organelles which have key roles in a
variety of cellular functions such as energy producing, regulation of calcium flux, cellular …

Sonic hedgehog (Shh) signaling influences neurogenesis and neural patterning during the
development of central nervous system. Dysregulation of Shh signaling in brain leads to …

Curcumin, which is the effective component of turmeric (Curcuma longa), has previously
been shown to exert potent antioxidant, antitumor and anti‑inflammatory activities in vitro …

Purpose Glioblastoma multiforme (GBM) is the primary aggressive malignancy of the brain
with poor outcome. Curcumin analogues are polyphenolic compounds as the bioactive …

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide and mostly
affects men. Around 20% of its incidence is by familiar disposition due to hereditary …

Curcumin is a polyphenol compound extracted from Curcuma longa plant, is a molecule with
pleiotropic effects that suppresses transformation, proliferation and metastasis of malignant …

CD44 is a transmembrane cell adhesion molecule that is cleaved by the membrane
proteinase, a disintegrin and metalloproteinase 10 (ADAM10), on the cell surface via …

Depression is the most prevalent form of neuropsychiatric disorder affecting all age groups
globally. As per the estimation of the World Health Organization (WHO), depression will …