The roles of nucleoid-associated proteins and topoisomerases in chromosome structure, strand segregation, and the generation of phenotypic heterogeneity in …

V Norris, C Kayser, G Muskhelishvili… - FEMS Microbiology …, 2023 - academic.oup.com
How to adapt to a changing environment is a fundamental, recurrent problem confronting
cells. One solution is for cells to organize their constituents into a limited number of spatially …

Enteropathogenic Escherichia coli—A Summary of the Literature

AD Mare, CN Ciurea, A Man, B Tudor… - Gastroenterology …, 2021 - mdpi.com
Diarrheal disease is still a major public health concern, as it is still considered an important
cause of death in children under five years of age. A few decades ago, the detection of …

Pervasive transcription enhances the accessibility of H-NS–silenced promoters and generates bistability in Salmonella virulence gene expression

N Figueroa-Bossi… - Proceedings of the …, 2022 - National Acad Sciences
In Escherichia coli and Salmonella, many genes silenced by the nucleoid structuring protein
H-NS are activated upon inhibiting Rho-dependent transcription termination. This response …

Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion

JPR Connolly, SL Slater, N O'Boyle… - Nature …, 2018 - nature.com
Niche-adaptation of a bacterial pathogen hinges on the ability to recognize the complexity of
signals from the environment and integrate that information with the regulation of genes …

Pangenome-level analysis of nucleoid-associated proteins in the Acidithiobacillia class: insights into their functional roles in mobile genetic elements biology

S Beard, A Moya-Beltrán, D Silva-García… - Frontiers in …, 2023 - frontiersin.org
Mobile genetic elements (MGEs) are relevant agents in bacterial adaptation and
evolutionary diversification. Stable appropriation of these DNA elements depends on host …

Here, there, and everywhere: How pathogenic Escherichia coli sense and respond to gastrointestinal biogeography

SE Woodward, Z Krekhno, BB Finlay - Cellular Microbiology, 2019 - Wiley Online Library
Gastrointestinal (GI) pathogens enteropathogenic and enterohaemorrhagic Escherichia coli
(EPEC and EHEC), and related mouse pathogen Citrobacter rodentium, are referred to as …

Environment Controls LEE Regulation in Enteropathogenic Escherichia coli

A Platenkamp, JL Mellies - Frontiers in microbiology, 2018 - frontiersin.org
Enteropathogenic Escherichia coli (EPEC) is a significant cause of infant morbidity and
mortality in developing regions of the world. Horizontally acquired genetic elements encode …

肠出血性大肠埃希氏菌致病机制研究进展.

杨小平, 郦娟, 虞伟明, 陈琼… - Journal of Food Safety & …, 2023 - search.ebscohost.com
肠出血性大肠埃希氏菌(enterohemorrhagic Escherichia coli, EHEC) 是一类能引起轻则水样
腹泻, 重则溶血尿毒综合征的重要肠道致病菌. EHEC 通过感知定殖部位的生物素和核酸浓度 …

Control freaks—signals and cues governing the regulation of virulence in attaching and effacing pathogens

NCA Turner, JPR Connolly… - Biochemical Society …, 2019 - portlandpress.com
Enterohaemorrhagic Escherichia coli (EHEC) mediates disease using a type 3 secretion
system (T3SS), which is encoded on the locus of enterocyte effacement (LEE) and is tightly …

GrlR, a negative regulator in enteropathogenic E. coli, also represses the expression of LEE virulence genes independently of its interaction with its cognate partner …

C Lara-Ochoa, A Huerta-Saquero… - Frontiers in …, 2023 - frontiersin.org
Introduction Enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. coli (EHEC)
and Citrobacter rodentium (CR) belong to a group of pathogens that share the ability to form …