Cancer epigenomics: beyond genomics
J Sandoval, M Esteller - Current opinion in genetics & development, 2012 - Elsevier
For many years cancer research has focused on genetic defects, but during the last decade
epigenetic deregulation has been increasingly recognized as a hallmark of cancer. The …
epigenetic deregulation has been increasingly recognized as a hallmark of cancer. The …
Epigenetic mechanisms in inflammation
D Bayarsaihan - Journal of dental research, 2011 - journals.sagepub.com
Epigenetic modifications occur in response to environmental changes and play a
fundamental role in gene expression following environmental stimuli. Major epigenetic …
fundamental role in gene expression following environmental stimuli. Major epigenetic …
A survey of small RNAs in human sperm
BACKGROUND There has been substantial interest in assessing whether RNAs (mRNAs
and sncRNAs, ie small non-coding) delivered from mammalian spermatozoa play a …
and sncRNAs, ie small non-coding) delivered from mammalian spermatozoa play a …
Epigenetic modifications of c-MYC: Role in cancer cell reprogramming, progression and chemoresistance
Both genetic and epigenetic mechanisms intimately regulate cancer development and
chemoresistance. Different genetic alterations are observed in multiple genes, and most are …
chemoresistance. Different genetic alterations are observed in multiple genes, and most are …
Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer
Axl is a receptor that induces proliferation, migration and invasion in cancer. In this study, we
show that specific microRNAs (miRNAs) target the 3′-UTR of Axl. Luciferase-reporter …
show that specific microRNAs (miRNAs) target the 3′-UTR of Axl. Luciferase-reporter …
Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells
Background The microRNA-200 family participates in the maintenance of an epithelial
phenotype and loss of its expression can result in epithelial to mesenchymal transition …
phenotype and loss of its expression can result in epithelial to mesenchymal transition …
[HTML][HTML] miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer
M Xin, Z Qiao, J Li, J Liu, S Song, X Zhao, P Miao… - Oncotarget, 2016 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are non-coding small RNAs that function as negative regulators of
gene expression involving in the tumor biology. ATP citrate lyase (ACLY), a key enzyme …
gene expression involving in the tumor biology. ATP citrate lyase (ACLY), a key enzyme …
Epigenetics in prostate cancer: biologic and clinical relevance
C Jerónimo, PJ Bastian, A Bjartell, GM Carbone… - European urology, 2011 - Elsevier
CONTEXT: Prostate cancer (PCa) is one of the most common human malignancies and
arises through genetic and epigenetic alterations. Epigenetic modifications include DNA …
arises through genetic and epigenetic alterations. Epigenetic modifications include DNA …
miRNAs and cancer: an epigenetics view
M Malumbres - Molecular aspects of medicine, 2013 - Elsevier
microRNAs (miRNAs) are small, non-coding RNAs with critical roles in fine-tuning a wide
array of biological processes including development, metabolism, and homeostasis …
array of biological processes including development, metabolism, and homeostasis …
Curcumin―the paradigm of a multi-target natural compound with applications in cancer prevention and treatment
As cancer is a multifactor disease, it may require treatment with compounds able to target
multiple intracellular components. We summarize here how curcumin is able to modulate …
multiple intracellular components. We summarize here how curcumin is able to modulate …