When fully extended, one copy of the three billion base pair human genome reaches a
length of over two meters. Yet, it must be packaged into the nucleus of a cell with an average …

The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …

The association of nuclear DNA with histones to form chromatin is essential for temporal and
spatial control of eukaryotic genomes. In this study, we examined the physical state of …

Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight
into how nucleosomes are arranged in vivo, we combined quantitative super-resolution …

Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the
membraneless compartmentalization of the nucleus. Because chromatin compaction and …

The proposal of a double‐helical structure for DNA over 60 years ago provided an eminently
satisfying explanation for the heritability of genetic information. But why is DNA, and not …

In vivo, the human genome folds into a characteristic ensemble of 3D structures. The
mechanism driving the folding process remains unknown. We report a theoretical model for …

Although chromatin organization and dynamics play a critical role in gene transcription, how
they interplay remains unclear. To approach this issue, we investigated genome-wide …

Revealing the energy landscape for nucleosome association may contribute to the
understanding of higher-order chromatin structures and their impact on genome regulation …

In eukaryotes, DNA is organized together with histones and non-histone proteins into a
highly complex nucleoprotein structure called chromatin, with the nucleosome as its …