Self-driving laboratories for chemistry and materials science

G Tom, SP Schmid, SG Baird, Y Cao, K Darvish… - Chemical …, 2024 - ACS Publications
Self-driving laboratories (SDLs) promise an accelerated application of the scientific method.
Through the automation of experimental workflows, along with autonomous experimental …

Modern approaches in the discovery and development of plant-based natural products and their analogues as potential therapeutic agents

A Najmi, SA Javed, M Al Bratty, HA Alhazmi - Molecules, 2022 - mdpi.com
Natural products represents an important source of new lead compounds in drug discovery
research. Several drugs currently used as therapeutic agents have been developed from …

Integrative analysis of multimodal mass spectrometry data in MZmine 3

R Schmid, S Heuckeroth, A Korf, A Smirnov… - Nature …, 2023 - nature.com
Innovation in mass spectrometry (MS) and the rapidly increasing throughput and sensitivity
of MS instrumentation require adaptations and innovations in data processing tools. Here …

antiSMASH 6.0: improving cluster detection and comparison capabilities

K Blin, S Shaw, AM Kloosterman… - Nucleic acids …, 2021 - academic.oup.com
Many microorganisms produce natural products that form the basis of antimicrobials,
antivirals, and other drugs. Genome mining is routinely used to complement screening …

Identification and prioritization of environmental organic pollutants: from an analytical and toxicological perspective

T Ruan, P Li, H Wang, T Li, G Jiang - Chemical Reviews, 2023 - ACS Publications
Exposure to environmental organic pollutants has triggered significant ecological impacts
and adverse health outcomes, which have been received substantial and increasing …

Emergence of methicillin resistance predates the clinical use of antibiotics

J Larsen, CL Raisen, X Ba, NJ Sadgrove… - Nature, 2022 - nature.com
The discovery of antibiotics more than 80 years ago has led to considerable improvements
in human and animal health. Although antibiotic resistance in environmental bacteria is …

Mass spectrometry-based metabolomics in microbiome investigations

A Bauermeister, H Mannochio-Russo… - Nature Reviews …, 2022 - nature.com
Microbiotas are a malleable part of ecosystems, including the human ecosystem.
Microorganisms affect not only the chemistry of their specific niche, such as the human gut …

Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity

RH Mills, PS Dulai, Y Vázquez-Baeza, C Sauceda… - Nature …, 2022 - nature.com
Ulcerative colitis (UC) is driven by disruptions in host–microbiota homoeostasis, but current
treatments exclusively target host inflammatory pathways. To understand how host …

Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials

S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation

M Arifuzzaman, TH Won, TT Li, H Yano, S Digumarthi… - Nature, 2022 - nature.com
Dietary fibres can exert beneficial anti-inflammatory effects through microbially fermented
short-chain fatty acid metabolites,, although the immunoregulatory roles of most fibre diets …