Copper is one of the most abundant basic transition metals in the human body. It takes part
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …

Elevated concentration of the homocysteine (Hcy) in human tissues, resulting either from
mutations in genes enconding Hcy-metabolizing enzymes, or from deficiences of folic acid …

Background/objective A Paleolithic diet may improve fatigue and quality of life in progressive
multiple sclerosis (MS) patients, but past research has evaluated the effects of this dietary …

Aim: Homocysteine (Hcy) can elicit neuronal cell death, and hyperhomocysteinemia is a
strong independent risk factor for Alzheimer's disease. The aim of this study was to examine …

Chronic arsenic exposure has been associated to cognitive deficits. However, mechanisms
remain unknown. The present study investigated the neurotoxic effects of sodium arsenite in …

Multiple sclerosis (MS) is a complex autoimmune disease that impairs the central nervous
system (CNS). The neurological disability and clinical course of the disease is highly …

BACKGROUND & AIMS: Wilson's disease (WND) is an autosomal recessive disorder of
copper (Cu) transport, resulting from pathogenic mutations in the ATP7B gene. The reason …

Objectives: A correlation between hyperhomocysteinemia, and depression has been
reported. Saffron (Crocus sativus) is recommended for treatment of depression; hence, in …

Background Dopamine replacement therapy by its precursor, L-3.4-dihydroxyphenylalanine
(L-DOPA), has been the treatment of choice for Parkinson's disease. However, the possible …

Elevated homocysteine (Hcy) levels have been implicated in neurodevelopmental and
neurodegenerative disorders. Induction of oxidative stress and apoptosis has been reported …