Kinins are among the most potent autacoids involved in inflammatory, vascular and pain
processes. These short-lived peptides, including bradykinin, kallidin and T-kinin, are …

The direction that research takes for a particular mediator is often dictated by the
circumstances of its discovery. In the case of the kinins, it was soon realised that bradykinin …

Numerous peptides appear to be neurotransmitter candidates in the brain. Some, such as
the opioid peptide enkephalins, neurotensin, and substance P, were first isolated from the …

The antinociceptive and hypothermic effects of intracisternal administration of 11
endogenous neuropeptides and morphine were evaluated in mice. Of the substances …

Auricular electro-stimulation (electroacupuncture) was found to produce naloxone-reversible
analgesia in the rat. These behavioral effects were accompanied by significant increases in …

The radioreceptor assay was used to examine the distribution of bombesin receptors in the
rat brain. The highest concentrations of receptors appeared to be associated with limbic …

Publisher Summary This chapter focuses on the development, mechanism of action, and
biological activity of two distinct classes of therapeutically useful inhibitors of angiotensin …

Bradykinin-like immunoreactive structures were localized in rat brain by the indirect
immunofluorescence method. Specificity of staining was demonstrated by:(i) the absence of …

Bradykinin and Lys-bradykinin are potent peptide mediators implicated in several
physiopathological effects in mammals. They act through activation of G-protein-coupled …

We have detected tissue kallikrein and kallikrein mRNA in various brain regions with a
kallikrein direct RIA and with nucleic acid hybridization using a kallikrein cDNA probe. In the …