A molecular biology–based taxonomy has been proposed for pheochromocytoma and
paraganglioma (PPGL). Data from the Cancer Genome Atlas revealed clinically relevant …

The past decades of advancements in NMR have made it a very powerful tool for metabolic
research. Despite its limitations in sensitivity relative to mass spectrometric techniques, NMR …

Phaeochromocytomas and paragangliomas (PPGLs) are neural-crest-derived tumours of
the sympathetic or parasympathetic nervous system that are often inherited and are …

Purpose Metabolic aberrations have been described in neoplasms with pathogenic variants
(PV) in the Krebs cycle genes encoding succinate dehydrogenase (SDH), fumarate …

The citric acid cycle, also known as the Krebs cycle, plays an integral role in cellular
metabolism and aerobic respiration. Mutations in genes encoding the citric acid cycle …

The tremendous advances over the past two decades in both clinical genetics and
biochemical testing of chromaffin cell tumours have led to new considerations about how …

Pheochromocytomas and paragangliomas (PPGLs), rare chromaffin/neural crest cell tumors,
are commonly benign in their clinical presentation. However, there are a number of cases …

Succinate dehydrogenase inhibitors (SDHi) are fungicides used to control the proliferation of
pathogenic fungi in crops. Their mode of action is based on blocking the activity of succinate …

Succinate dehydrogenase is a key enzyme in the tricarboxylic acid cycle and the electron
transport chain. All four subunits of succinate dehydrogenase are tumor suppressor genes …

ABSTRACT Objective: Pheochromocytomas and paragangliomas (PPGLs) are
neuroendocrine tumors derived from adrenal or extra-adrenal locations, respectively. Upon …