Studies on signal transduction pathways have generated various promising molecular
targets for therapeutic inhibition in cancer therapy. Receptor tyrosine kinases represent an …

Introduction: Under normal conditions, hepatocyte growth factor (HGF)-induced activation of
its cell surface receptor, the Met tyrosine kinase (TK), is tightly regulated by paracrine ligand …

Invasion and metastasis increase after the inhibition of VEGF signaling in some preclinical
tumor models. In the present study we asked whether selective VEGF inhibition is sufficient …

Patients presenting with metastatic rhabdomyosarcoma (RMS), the most common soft-tissue
sarcoma in children, have a very poor clinical prognosis. This is due, in large part, to our …

Under normal conditions, hepatocyte growth factor (HGF)-induced Met tyrosine kinase (TK)
activation is tightly regulated by paracrine ligand delivery, ligand activation at the target cell …

Hepatocyte growth factor (HGF)/c-Met signaling is thought to be a key pathway in both
melanocyte development and melanoma metastasis. Here, HGF stimulation of melanocytes …

The vast majority of deaths associated with cancer are a consequence of a complex
phenotypic behavior, metastasis, by which tumor cells spread from their primary site of origin …

Hepatocyte growth factor receptor (HGFR), the product of the MET gene, plays an important
role in normal cellular function and oncogenesis. In cancer, HGFR has been implicated in …

Background Melanoma is notorious for its propensity to metastasize, which makes treatment
extremely difficult. Receptor tyrosine kinase c-Met is activated in human melanoma and is …

Receptor tyrosine kinases have come to fruition as therapeutic targets in a variety of
malignancies. In this group of targets, the c-Met receptor tyrosine kinase plays an important …